Deep dermatophytosis is a dermal infection caused by Dermatophytes. It can cause deeper dermal dermatophytosis, Majocchi's granuloma, dermatophytic pseudomycetoma or a widespread infection. CARD9 deficiency is a known risk factor in the Mediterranean region, first reported in 1964 in Morocco. We report a case of 23-year-old man with a scarring alopecia who presented with subcutaneous abscesses topped off with a large ringworm infection. Mycotic analysis revealed a Trichophyton Rubrum deep dermatophytosis. The molecular study revealed a CARD9 mutation confirming dermatophytosis with parotid and lymph nodes involvement. The patient underwent successful drainage surgery of the abscesses alongside medical treatment including antifungal agents and he was discharged after an uneventful postoperative course.
Kaposi's sarcoma (KS) is a proliferative and multifocal disease with a double vascular and fibroblastic cell component, of mucocutaneous and visceral expression. It is a multifocal tumoral process, hyperplastic in nature without metastatic potential, induced by the human herpes virus 8 (HHV8). Paraneoplastic syndromes (PS) in KS are rare, with only a small number of cases reported and we have found no previous descriptions of a paraneoplastic scleroderma in KS in the literature. We report the cases of two patients with this atypical PS.
Sneddon-Wilkinson disease is a benign amicrobial pustulosis belonging to the spectrum of neutrophilic dermatoses. It is characterized by evident stereotypic clinical features, including, in most cases, pustular lesions of the trunk and prominent skin folds. This pustulosis may be associated with other diseases (IgA monoclonal gammopathy, rheumatoid arthritis, neoplasms or other neutrophilic dermatoses) and therefore requires regular follow-up. This disease has a relapsing-remitting course. First line therapy is dapsone. We here report the case of a 49-year-old patient with amicrobial pustulosis (Sneddon-Wilkinson disease).
Arthritis, Rheumatoid , Dermatitis , Skin Diseases, Vesiculobullous , Humans , Middle Aged , Blister , Dapsone
Seborrhoeic keratoses (SK) are benign tumors that mainly occur in the head and in the trunk. Their size generally varies from a few millimeters up to a few centimeters. Giant lesions are very rare but pose a problem in terms both of treatment and transformation. Their occurrence in the genital area is even more rare, posing a problem in differential diagnosis of genital warts. Differentiation is only based on histopathology. We report the case of a 80-year old man, with no particular past medical history, who presented with asymptomatic abdominal and genital lesions evolving over the last twenty years. Clinical examination showed four hyperpigmented, humped, well-defined tumors, with warty surface measuring 2-10 cm along its longer axis (A). Dermoscopic examination showed cerebriform convolutions appearance suggesting seborrhoeic keratoses (B). Histology confirmed the diagnosis, without signs of viral infection or malignant transformation. The patient underwent surgical resection resulting in permanent scar.
Condylomata Acuminata/diagnosis , Dermoscopy/methods , Genital Diseases, Male/diagnosis , Keratosis, Seborrheic/diagnosis , Aged, 80 and over , Condylomata Acuminata/surgery , Diagnosis, Differential , Genital Diseases, Male/pathology , Genital Diseases, Male/surgery , Humans , Keratosis, Seborrheic/surgery , Male
Kaposi disease (KD) is an angiogenetic tumor process, characterized by its various clinical aspects. Its pathogenesis is multifactorial and it was attributed to HHV-8 infection. We report an original case of disseminated KD revealed by solitary lesion of external ear in a patient treated by corticosteroids for bullous pemphigoid.
Ear Auricle , Ear Neoplasms/pathology , Xeroderma Pigmentosum/pathology , Colonic Neoplasms/diagnosis , Ear Neoplasms/diagnosis , Female , Humans , Liver Neoplasms/diagnostic imaging , Middle Aged , Skin/pathology , Splenic Neoplasms/diagnostic imaging , Stomach Neoplasms/diagnosis , Tomography, X-Ray Computed , Xeroderma Pigmentosum/diagnostic imaging
Lymphangioma/etiology , Neoplasms, Radiation-Induced/etiology , Radiotherapy, Adjuvant/adverse effects , Vulvar Neoplasms/etiology , Biopsy , Combined Modality Therapy , Female , Humans , Hysterectomy , Laser Therapy , Lasers, Gas/therapeutic use , Lymphangioma/pathology , Lymphangioma/surgery , Middle Aged , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/surgery , Uterine Cervical Neoplasms/radiotherapy , Uterine Cervical Neoplasms/surgery , Vulvar Neoplasms/pathology , Vulvar Neoplasms/surgery
Crohn Disease/complications , Edema/etiology , Vulvar Diseases/etiology , Adrenal Cortex Hormones/therapeutic use , Anus Diseases/etiology , Crohn Disease/drug therapy , Crohn Disease/pathology , Drug Combinations , Drug Substitution , Female , Glucosamine/analogs & derivatives , Glucosamine/therapeutic use , Granuloma/etiology , Humans , Immunosuppressive Agents/therapeutic use , Infliximab/therapeutic use , Middle Aged , Proctitis/etiology , Rituximab/therapeutic use , Sulfasalazine/therapeutic use
Lichen sclerosus et atrophicus is a chronic inflammatory dermatosis, characterized by a specific external genital mucosal tissue tropism. Isolated cutaneous manifestation is rare. We report a case of lichen sclerosus et atrophicus in a woman with purely cutaneous involvement, in order to highlight the importance of evoking this diagnosis in the absence of obvious genital involvement.
Lichen Sclerosus et Atrophicus/diagnosis , Skin/pathology , Female , Humans , Lichen Sclerosus et Atrophicus/pathology , Middle Aged
Penile Diseases/microbiology , Skin Ulcer/microbiology , Tuberculosis, Male Genital , Humans , Male , Middle Aged , Penile Diseases/diagnosis , Penile Diseases/drug therapy , Skin Ulcer/diagnosis , Skin Ulcer/drug therapy , Tuberculosis, Male Genital/diagnosis , Tuberculosis, Male Genital/drug therapy
